Description

Penicillin F Potassium Salt is a naturally occurring penicillin antibiotic, specifically the potassium salt of Penicillin F (2-Pentenylpenicillin). This compound serves as a crucial reference standard and research-grade biochemical for analytical and developmental purposes. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic kits for studying β-lactam antibiotics, microbial resistance, and antibiotic biosynthesis pathways.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, LC-MS) of penicillin compounds in research and quality control laboratories.
• Antibiotic Research: Serves as a key biochemical tool in studies related to antibiotic mechanism of action, bacterial resistance patterns, and the development of novel β-lactamase inhibitors.
• Microbiological Studies: Employed in microbiological assays to determine antibiotic potency and to study the structure-activity relationships (SAR) within the penicillin class.
• Enzymology Substrate: Acts as a substrate for enzymes like β-lactamases in kinetic studies and enzyme characterization experiments.
• Diagnostic Manufacturing: Used in the production and calibration of diagnostic assays and kits designed to detect penicillin residues or specific antibiotic sensitivities.
• Biochemical Synthesis: Functions as an intermediate or precursor in the research-scale synthesis of specialized penicillin derivatives or labeled compounds for tracer studies.

Basic Information

Product Name	Penicillin F Potassium Salt
CAS No.	97299-13-3
Molecular Formula	C14H19KN2O4S
Molecular Weight	350.48 g/mol
Synonyms	(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-pentenoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt; Potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-pentenoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; 2-Pentenylpenicillin Potassium Salt; Penicillin I Potassium Salt; F-Penicillin Potassium Salt; Amylpenicillin Potassium Salt; δ-2-Pentenylpenicillin Potassium
EINECS	Contact for details

Quality Control

Our Penicillin F Potassium Salt is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided, documenting critical parameters such as assay, related substances, and residual solvents. We support compliance with relevant pharmacopeial guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Potassium Content	10.5% - 12.0%
pH (in solution)	5.5 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.