Description

2'-Deoxyguanosine 3',5'-Diphosphoimidazolide is a high-purity, activated nucleotide derivative essential for oligonucleotide synthesis. This compound matters as a critical building block for creating specific DNA sequences with high coupling efficiency, enabling advanced research and therapeutic development. It is primarily needed by biotechnology and pharmaceutical companies engaged in antisense oligonucleotide synthesis, aptamer development, and other nucleic acid-based applications.

Application

• Solid-Phase Oligonucleotide Synthesis: As an activated monomer for the automated, stepwise assembly of DNA strands.
• Antisense Oligonucleotide (ASO) Production: A key raw material in the manufacture of therapeutic ASOs targeting specific mRNA sequences.
• Aptamer Development: Used in the chemical synthesis of DNA aptamers for diagnostic and therapeutic purposes.
• Research & Development: For the custom synthesis of DNA probes, primers, and gene fragments in academic and industrial labs.
• Labeled Nucleotide Synthesis: Serving as a precursor for the preparation of fluorescently or chemically tagged nucleotides.
• Nucleic Acid Chemistry Studies: A reagent for investigating phosphorylation mechanisms and enzymatic mimicry in prebiotic chemistry.

Basic Information

Product Name	2'-Deoxyguanosine 3',5'-Diphosphoimidazolide
CAS No.	96886-66-7
Molecular Formula	C13H17N6O10P2
Molecular Weight	479.26 g/mol
Synonyms	Imidazolide of 2'-Deoxyguanosine 3',5'-Diphosphate; dGppIm; 2'-Deoxyguanosine 3',5'-diphospho-1-imidazolide; Guanosine, 2'-deoxy-, 3',5'-(hydrogen diphosphate) 1-(imidazolide); 2'-Deoxyguanosine 3',5'-bisphosphate imidazolide; ImGppdG; Activated dGDP
EINECS	Contact for details

Quality Control

Our 2'-Deoxyguanosine 3',5'-Diphosphoimidazolide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for nucleic acid synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.