Description

Methyclothiazide is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the thiazide diuretic class. It is a critical component in the synthesis of antihypertensive and diuretic medications, valued for its consistent quality and reliable performance. This compound is essential for manufacturers in the pharmaceutical industry engaged in the research, development, and production of cardiovascular therapies. We supply Methyclothiazide CAS NO 96783-15-2 to meet the stringent demands of global GMP-compliant manufacturing.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the formulation of prescription diuretic and antihypertensive drugs.
• Cardiovascular Drug Manufacturing: A key intermediate in the production of medications for managing edema associated with congestive heart failure, liver cirrhosis, and renal dysfunction.
• Hypertension Treatment Formulations: Used in combination therapies for the effective control of high blood pressure.
• Reference Standard: Serves as a high-purity analytical standard in quality control (QC) and research & development (R&D) laboratories for method development and validation.
• Biochemical Research: Utilized in pharmacological studies to investigate renal electrolyte transport mechanisms and diuretic action.
• Generic Drug Production: A vital raw material for manufacturers producing generic versions of branded thiazide diuretic medications.

Basic Information

Product Name	Methyclothiazide
CAS No.	96783-15-2
Molecular Formula	C₉H₁₁Cl₂N₃O₄S₂
Molecular Weight	360.24 g/mol
Synonyms	6-Chloro-3,4-dihydro-3-[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Methylchlorothiazide; Enduron; Aquatensen; 3-[(2,2,2-Trifluoroethyl)thiomethyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Methyclothiazidum; NSC-113019
EINECS	Contact for details

Quality Control

Our Methyclothiazide is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other pharmacopeial methods. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.