Description

Methyclothiazide is a potent thiazide diuretic and antihypertensive agent belonging to the benzothiadiazine class. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the management of hypertension (high blood pressure).
• Edema Treatment: Formulation into diuretic drugs used to treat fluid retention (edema) associated with conditions such as congestive heart failure, liver cirrhosis, and renal dysfunction.
• Combination Therapies: Utilized in fixed-dose combination drugs with other antihypertensive agents for enhanced therapeutic effect.
• Pharmacological Research: Serves as a reference standard and key intermediate in cardiovascular and renal disease research.
• Generic Drug Manufacturing: Essential for the production of cost-effective generic versions of branded diuretic medications.
• Clinical Trial Material: Supplied as a high-grade material for preclinical and clinical studies investigating new treatment regimens.

Basic Information

Product Name	Methyclothiazide
CAS No.	96783-14-1
Molecular Formula	C9H11Cl2N3O4S2
Molecular Weight	360.24 g/mol
Synonyms	6-Chloro-3-(chloromethyl)-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Methylchlorothiazide; Enduron; Aquatensen; 3-(Chloromethyl)-6-chloro-2-methyl-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Meticlotiazide; NSC-113019
EINECS	Contact for details

Quality Control

Our Methyclothiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines and current Good Manufacturing Practices (cGMP). A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.