Description

Trichlormethiazide is a high-potency thiazide diuretic and antihypertensive agent, widely recognized for its clinical efficacy. Its primary value lies in its potent pharmacological activity, which allows for effective management of fluid retention and high blood pressure at lower doses. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing cardiovascular medications, particularly diuretics and combination antihypertensive drugs.

Application

• Active Pharmaceutical Ingredient (API) in antihypertensive medications.
• Core component in diuretic formulations for treating edema associated with heart failure, liver cirrhosis, and renal disease.
• Key intermediate in advanced pharmaceutical research for cardiovascular therapies.
• Reference standard in analytical laboratories for quality control and method development.
• Used in clinical studies investigating novel treatment regimens for hypertension.
• Essential material for compounding pharmacies requiring specific diuretic agents.

Basic Information

Product Name	Trichlormethiazide
CAS No.	96783-12-9
Molecular Formula	C8H8Cl3N3O4S2
Molecular Weight	380.65 g/mol
Synonyms	6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Naqua; Metahydrin; Flomet; Diurese; Salurin; Trichlormethiazidum; Benzothiadiazine derivative
EINECS	Contact for details

Quality Control

Our Trichlormethiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any individual impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.