Description

(-)-Cyclopenthiazide CAS NO 96783-06-1 is the specific enantiomer of the thiazide-class diuretic agent, cyclopenthiazide. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in studying stereospecific biological activity and metabolism. It is primarily required by pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers of active pharmaceutical ingredients (APIs) for method development and quality control.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of cyclopenthiazide in drug substances and finished products.
• Active Pharmaceutical Ingredient (API) R&D: Used in preclinical and clinical research to investigate the pharmacokinetics, pharmacodynamics, and efficacy of the specific (-)-enantiomer.
• Metabolite and Impurity Profiling: Essential for developing and validating analytical methods (HPLC, LC-MS) to identify and quantify related substances in pharmaceutical formulations.
• Chiral Pharmacology Studies: Enables research into the stereoselective interactions, receptor binding, and therapeutic effects compared to its enantiomer or racemic mixture.
• Quality Control Laboratories: Employed as a system suitability and identification standard in compliance testing for drug manufacturers.

Basic Information

Product Name	(-)-Cyclopenthiazide
CAS No.	96783-06-1
Molecular Formula	C13H18ClN3O4S2
Molecular Weight	379.88 g/mol
Synonyms	(-)-6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; (3R)-6-Chloro-3-(cyclopentylmethyl)-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Levocyclopenthiazide; NSC 107671; S(-)-Cyclopenthiazide; Cyclopenthiazide Enantiomer; Cyclopenthiazide (-)-Isomer
EINECS	Contact for details

Quality Control

Our (-)-Cyclopenthiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling via advanced techniques like HPLC and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high enantiomeric purity and reliable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.