Description

Ethiazide is a high-purity thiazide diuretic compound, essential for pharmaceutical research and development. Its primary value lies in its role as a key intermediate and reference standard in the synthesis and quality control of antihypertensive and diuretic medications. This product is critical for pharmaceutical manufacturers, analytical laboratories, and R&D facilities focused on cardiovascular drug development and regulatory compliance.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of thiazide-class diuretic and antihypertensive active pharmaceutical ingredients (APIs).
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of finished drug products and raw materials.
• Biochemical Research: Employed in pharmacological studies to investigate diuretic mechanisms, electrolyte transport, and renal function.
• Formulation Development: Serves as a model compound for developing stable and bioavailable solid dosage forms, such as tablets and capsules.
• Regulatory Compliance: Essential for generating data to support drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).

Basic Information

Product Name	Ethiazide
CAS No.	1824-58-4
Molecular Formula	C₈H₈ClN₃O₄S₂
Molecular Weight	317.76 g/mol
Synonyms	6-Chloro-3,4-dihydro-2-methyl-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Chloro-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; Etiazide; Ethyazide; NSC-107679; Flumethiazide (related analog); Benzothiadiazine derivative
EINECS	217-354-4

Quality Control

Our Ethiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other pharmacopeial methods, to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed-upon standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.