Description

(+)-Cyclopenthiazide CAS NO 96783-05-0 is the pharmacologically active enantiomer of cyclopenthiazide, a potent thiazide diuretic. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in the study of stereospecific drug action and renal physiology. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of reference standards and active pharmaceutical ingredients (APIs) for hypertension and edema management.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method development in API and finished drug product manufacturing.
• Stereochemical Research: Used as a pure enantiomer in pharmacological studies to investigate the specific biological activity, metabolism, and pharmacokinetics of the (+)-enantiomer separate from its racemic mixture.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and development of enantiomerically pure diuretic and antihypertensive medications.
• Biochemical Research: A tool compound for studying the mechanism of action of thiazide diuretics on the Na+-Cl- cotransporter in the distal convoluted tubule of the kidney.
• Analytical Method Development: Essential for developing and validating chiral separation methods, such as chiral HPLC or CE, for pharmacokinetic and bioequivalence studies.

Basic Information

Product Name	(+)-Cyclopenthiazide
CAS No.	96783-05-0
Molecular Formula	C13H18ClN3O4S2
Molecular Weight	379.88 g/mol
Synonyms	(+)-6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; (3R)-6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Dextro-Cyclopenthiazide; (R)-Cyclopenthiazide; NSC 107428; Cyclopenthiazide enantiomer; Cyclopenthiazide (+)-form
EINECS	Contact for details

Quality Control

Our (+)-Cyclopenthiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), chiral excess, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.