Description

(-)-Benzylhydrochlorothiazide CAS NO 96782-98-8 is a specific stereoisomer of a benzylated derivative of hydrochlorothiazide, a well-known diuretic and antihypertensive agent. This enantiomerically pure compound is of significant interest in advanced pharmaceutical research and development, particularly for studying structure-activity relationships and metabolic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), metabolite identification, and the development of high-purity reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified material for analytical method development, validation, and quality control testing in regulatory submissions.
• Active Pharmaceutical Ingredient (API) Intermediate: Used as a key chiral building block in the synthetic pathways for novel diuretic or antihypertensive drug candidates.
• Metabolite Research: Employed in pharmacokinetic and metabolic studies to identify and characterize specific stereoisomeric metabolites of related drugs.
• Biochemical Research: Acts as a tool compound for investigating the mechanism of action and receptor binding affinity of thiazide derivatives.
• Process Chemistry Development: Utilized in optimizing and scaling up enantioselective synthesis routes within process R&D laboratories.

Basic Information

Product Name	(-)-Benzylhydrochlorothiazide
CAS No.	96782-98-8
Molecular Formula	C15H15ClN2O4S2
Molecular Weight	386.87 g/mol
Synonyms	(-)-6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, Benzyl Derivative; (S)-Benzylhydrochlorothiazide; Benzyl HCTZ; 3-Benzyl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 3-Benzyl Derivative; 6-Chloro-3-(phenylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; (-)-3-Benzyl-6-chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
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Quality Control

Our (-)-Benzylhydrochlorothiazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.