Description

(+)-Benzylhydrochlorothiazide CAS NO 96782-97-7 is a specific enantiomer of a benzylated derivative of hydrochlorothiazide, a well-known diuretic and antihypertensive agent. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in studying stereospecific biological activity and metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel cardiovascular therapeutics, analytical method development, and as a reference standard.

Application

• Pharmaceutical Reference Standard: Used for analytical method validation, quality control, and calibration in HPLC, GC, and other chromatographic systems.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthetic pathway for novel diuretic and antihypertensive drugs.
• Pharmacological Research: Employed in preclinical studies to investigate the stereoselective effects, pharmacokinetics, and receptor binding profiles of thiazide derivatives.
• Metabolite Studies: Used as a standard in the identification and quantification of drug metabolites in biological matrices during ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Process Chemistry & Optimization: Acts as a critical intermediate for process chemists to develop and scale up enantioselective synthesis routes.

Basic Information

Product Name	(+)-Benzylhydrochlorothiazide
CAS No.	96782-97-7
Molecular Formula	C15H15ClN2O4S2
Molecular Weight	386.88 g/mol
Synonyms	(+)-Benzyl Hydrochlorothiazide; (R)-Benzylhydrochlorothiazide; 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 3-benzyl-; 3-Benzyl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Benzyl HCTZ; BZ-HCTZ
EINECS	Contact for details

Quality Control

Our (+)-Benzylhydrochlorothiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet exacting standards for research use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, enantiomeric excess, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.