Description

(S)-Bacampicillin Hydrochloride is a semi-synthetic, broad-spectrum antibiotic belonging to the aminopenicillin class. It serves as a prodrug of ampicillin, offering enhanced oral bioavailability and stability, which is critical for effective pharmaceutical formulation. This high-purity active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical industry developing oral antibiotic medications and for research institutions conducting microbiological and pharmacological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of oral antibiotic tablets and capsules.
• Prodrug Research: A key compound in pharmacokinetic and drug delivery studies due to its esterified structure that improves absorption.
• Antibacterial Agent Development: Used in R&D for creating new antibiotic combinations and evaluating efficacy against susceptible organisms.
• Reference Standard: Serves as a high-purity chemical reference standard in quality control laboratories for analytical method development and validation.
• Microbiological Studies: Employed in in-vitro studies to determine minimum inhibitory concentrations (MICs) and study bacterial resistance mechanisms.

Basic Information

Product Name	(S)-Bacampicillin Hydrochloride
CAS No.	95530-84-0
Molecular Formula	C21H27N3O7S • HCl
Molecular Weight	501.98 g/mol
Synonyms	Bacampicillin HCl; (S)-1'-Ethoxycarbonyloxyethyl (6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrochloride; Ambaxin; Bacacil; Bacampicillin Hydrochloride; Spectrobid; Penbristol
EINECS	Contact for details

Quality Control

Our (S)-Bacampicillin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and microbiological tests is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can compromise stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.