Description

4-Deoxy-3'-Bromopyrido(1',2'-1,2)Imidazo(5,4-C)Rifamycin S is a chemically modified derivative of the potent ansamycin antibiotic rifamycin S, characterized by the introduction of a bromine atom and a deoxy sugar moiety on the complex polyketide core. This structural modification is of significant interest for the development of novel antibacterial agents and as a key synthetic intermediate in pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in antibiotic discovery, medicinal chemistry, and the synthesis of advanced bioactive compounds.

Application

• Pharmaceutical Research & Development: Serves as a critical synthetic intermediate and a lead compound in the discovery of next-generation antibiotics targeting resistant bacterial strains.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies to explore the impact of halogenation and sugar modification on the biological activity of rifamycin analogs.
• Biochemical Research: Employed as a tool compound to study bacterial RNA polymerase inhibition mechanisms and explore novel modes of antibacterial action.
• Chemical Synthesis: Acts as a versatile building block for the semi-synthesis of more complex rifamycin derivatives with tailored properties.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis, antibiotic resistance, and microbial pharmacology.

Basic Information

Product Name	4-Deoxy-3'-Bromopyrido(1',2'-1,2)Imidazo(5,4-C)Rifamycin S
CAS No.	95360-35-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3'-Bromo-4-deoxypyrido[1',2':1,2]imidazo[5,4-c]rifamycin S; 4-Deoxy-3'-bromopyrido[1',2':1,2]imidazo[5,4-c]rifamycin; Brominated Rifamycin S Derivative; 4-Deoxy-3'-bromo-PIR S; Ansamycin antibiotic derivative; Rifamycin analog; Antibacterial research compound
EINECS	Contact for details

Quality Control

Every batch of 4-Deoxy-3'-Bromopyrido(1',2'-1,2)Imidazo(5,4-C)Rifamycin S is manufactured and tested under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.