Description

Poly-5-Methylthiouridylic Acid is a chemically modified nucleotide polymer, specifically a homopolymer of 5-methyluridine monophosphate. This compound is a critical synthetic analog used in advanced biochemical research and development, offering unique properties for studying nucleic acid structure, function, and interactions. It is primarily utilized by research institutions and biotechnology companies focused on molecular biology, enzymology, and the development of novel therapeutic and diagnostic platforms.

Application

• Biochemical Research: Serves as a substrate or template for studying RNA polymerase, reverse transcriptase, and other nucleic acid-processing enzymes.
• Nucleic Acid Analog Synthesis: Used as a building block in the synthesis of modified oligonucleotides with tailored stability and hybridization characteristics.
• Enzyme Kinetics & Inhibition Studies: Acts as a tool compound to investigate enzyme mechanisms and screen for potential inhibitors.
• Structural Biology: Employed in X-ray crystallography and NMR studies to understand the impact of base methylation on nucleic acid conformation.
• Diagnostic Probe Development: Potential use in the design of specialized probes for detecting specific RNA sequences or viral genomes.
• Cell Culture & Virology: May be used in specialized media formulations or as a component in studies of viral replication mechanisms.

Basic Information

Product Name	Poly-5-Methylthiouridylic Acid
CAS No.	94926-74-6
Molecular Formula	(C10H13N2O8P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(5-methyluridylic acid)
Poly(5-methyl-UMP)
Poly(m5U)
Poly(5-methyluridine 5'-monophosphate)
5-Methyl-UMP homopolymer
Poly(ribothymidylic acid)
Poly(rT)
EINECS	Contact for details

Quality Control

Our Poly-5-Methylthiouridylic Acid is produced under stringent conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including spectroscopic and chromatographic methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (UV/VIS)	Complies
Identification (HPLC)	Complies
Assay (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in aqueous buffers, slightly soluble in water
Endotoxin (LAL)	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.