Description

2,3,4,5-Tetrafluorobenzoyl Chloride is a highly reactive and versatile fluorinated aromatic acid chloride building block. Its value lies in its ability to efficiently introduce the multi-fluorinated benzoyl moiety into target molecules, significantly altering their electronic properties, lipophilicity, and metabolic stability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and stability.
• Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer chains, enhancing chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A crucial reagent for Friedel-Crafts acylation and amide coupling reactions in complex molecule construction within R&D laboratories.
• Advanced Material Research: Used in developing novel fluorinated dyes, pigments, and photoactive materials for specialized industrial applications.

Basic Information

Product Name	2,3,4,5-Tetrafluorobenzoyl Chloride
CAS No.	94695-48-4
Molecular Formula	C7HF4ClO
Molecular Weight	212.53 g/mol
Synonyms	2,3,4,5-Tetrafluorobenzoic acid chloride; Perfluorobenzoyl Chloride (ambiguous, but common); Benzoyl chloride, 2,3,4,5-tetrafluoro-; 2,3,4,5-Tetrafluorobenzoyl chloride; Tetrafluorobenzoyl chloride; NSC 405124; BRN 2934818
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrafluorobenzoyl Chloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment. Our quality systems support development and cGMP manufacturing requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability. Keep away from moisture, strong bases, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.