Description

(Pivaloyloxy)Methyl [6R-[6Alpha,7Beta(R*)]]-7-[(Aminophenylacetyl)Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Phosphate is a key pharmaceutical intermediate, specifically a prodrug form of a cephalosporin antibiotic. Its primary value lies in enhancing the bioavailability and stability of the active pharmaceutical ingredient (API) during formulation and storage. This compound is critically needed by manufacturers in the pharmaceutical industry engaged in the synthesis of advanced β-lactam antibiotics.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: As a crucial intermediate in the production of specific cephalosporin-class antibiotics.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for developing new antibiotic formulations and delivery systems.
• Prodrug Development: Serves as a model compound for studying ester-based prodrug strategies to improve drug solubility and absorption.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control and method validation.
• Antibiotic Manufacturing: Integral to the commercial-scale synthesis chain for finished dosage forms like injectables or oral medications.

Basic Information

Product Name	(Pivaloyloxy)Methyl [6R-[6Alpha,7Beta(R*)]]-7-[(Aminophenylacetyl)Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Phosphate
CAS No.	94088-99-0
Molecular Formula	C24H30N4O9PS
Molecular Weight	581.56 g/mol
Synonyms	Pivaloyloxymethyl Cefetamet Phosphate; Cefetamet Pivoxil Phosphate; Cefetamet Pivoxil Phosphate Ester; Ro 15-8075 Phosphate; (6R,7R)-7-[(2-Amino-2-phenylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester, phosphate; Cefetamet Pivoxil Phosphate Salt; POM Cefetamet Phosphate
EINECS	Contact for details

Quality Control

Our (Pivaloyloxy)Methyl Cefetamet Phosphate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.