Description

N7-(2',3',4'-Trihydroxybutyl)Guanine is a chemically modified nucleobase derivative, specifically a guanine analog with a trihydroxybutyl side chain at the N7 position. This structural modification is of significant interest in medicinal chemistry and biochemistry for the development of novel antiviral and anticancer agents. It serves as a key intermediate or active pharmaceutical ingredient (API) in advanced research and pharmaceutical synthesis. Target users include pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on nucleoside chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel nucleoside analog drugs.
• Antiviral Research: Investigated for its potential activity against viral targets due to its modified guanine structure.
• Oncology Research: Used in the development of chemotherapeutic agents that target DNA replication and repair mechanisms.
• Biochemical Tool: Serves as a substrate or inhibitor in enzymatic studies related to purine metabolism.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	N7-(2',3',4'-Trihydroxybutyl)Guanine
CAS No.	93905-80-7
Molecular Formula	C9H13N5O4
Molecular Weight	255.23 g/mol
Synonyms	N7-(2,3,4-Trihydroxybutyl)guanine; Guanine, N7-(2,3,4-trihydroxybutyl)-; 2-Amino-7-[(2,3,4-trihydroxybutyl)]-1H-purin-6(7H)-one; 7-(2,3,4-Trihydroxybutyl)guanine; THBG; N7-THB-Guanine
EINECS	Contact for details

Quality Control

Our N7-(2',3',4'-Trihydroxybutyl)Guanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.