Description

Dmt-Dg(Ib) Phosphoramidite is a specialized, high-purity nucleoside phosphoramidite building block used in automated oligonucleotide synthesis. This compound is critical for the solid-phase synthesis of DNA and RNA sequences, enabling precise control over genetic material assembly. It is an essential raw material for research institutions, diagnostic kit manufacturers, and pharmaceutical companies developing advanced therapeutics, including antisense oligonucleotides and siRNA.

Application

• Oligonucleotide Synthesis: As a key monomer for the automated solid-phase synthesis of custom DNA and RNA strands.
• Therapeutic Development: Production of antisense oligonucleotides, siRNA, and aptamers for targeted drug discovery and development.
• Diagnostic Probes: Manufacture of labeled probes and primers for PCR, qPCR, and next-generation sequencing (NGS) applications.
• Research Reagents: Synthesis of modified oligonucleotides for fundamental biochemical and biophysical research.
• CRISPR/Cas9 Components: Synthesis of guide RNAs (gRNAs) and other components for gene editing technologies.

Basic Information

Product Name	Dmt-Dg(Ib) Phosphoramidite
CAS No.	93183-15-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-dG(ib) Phosphoramidite; 2'-Deoxyguanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-[[[2-cyanoethoxy(diisopropylamino)phosphino]oxy]ethyl]-, 2-cyanoethyl diisopropylphosphoramidite; dG(Ib) Phosphoramidite; Guanosine Phosphoramidite, DMT-protected
EINECS	Contact for details

Quality Control

Our Dmt-Dg(Ib) Phosphoramidite is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by 31P NMR and mass spectrometry, to ensure it meets the high standards required for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.