Description

Teicoplanin A2-3 is a major glycopeptide antibiotic component derived from the fermentation of *Actinoplanes teichomyceticus*. This compound is critical for its potent bactericidal activity against Gram-positive pathogens, including methicillin-resistant *Staphylococcus aureus* (MRSA). It is an essential intermediate and reference standard in pharmaceutical research, development, and quality control for anti-infective therapeutics. Professionals in pharmaceutical manufacturing, analytical laboratories, and clinical research rely on its high purity for accurate bioassays and formulation studies.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and purity testing of teicoplanin in pharmacopeial methods (e.g., USP, EP).
• Antibiotic Research & Development: Serves as a key intermediate and active pharmaceutical ingredient (API) in the development of novel glycopeptide antibiotics and combination therapies.
• Microbiological Assays: Employed in microbiological potency tests and the calibration of agar diffusion or turbidimetric assays against susceptible bacterial strains.
• Analytical Method Development: Utilized for developing and validating HPLC, LC-MS, and other chromatographic methods for antibiotic analysis.
• In-vitro Studies: Applied in preclinical research to study mechanisms of action, resistance patterns, and the efficacy of teicoplanin components.

Basic Information

Product Name	Teicoplanin A2-3
CAS No.	91032-36-9
Molecular Formula	C88H95Cl2N9O33
Molecular Weight	1877.6 g/mol
Synonyms	Teicoplanin A2-3; Teicoplanin A2 component 3; Antibiotic MDL 621; Targocid component A2-3; Teichomycin A2-3; (4S)-4-[[(2S,3R,4S,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-Acetamido-5-[(2S,3S,4R,5S,6S)-4,5-dihydroxy-6-methyl-3-(2-methylpropanoylamino)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]amino]-2-[[(11S,14S,36R,37S,43S,44R,45S)-44-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(2-methylpropanoylamino)oxan-2-yl]oxy-14-ethyl-7,15-dichloro-4,37-dihydroxy-43-methoxy-11,45-dimethyl-10,13,16,41-tetraoxo-9-oxa-12,15,40-triazaoctacyclo[27.14.2.23,6.214,17.219,32.221,24.02,34.026,30]pentatetraconta-1(42),3,5,17,19,21,23,29(44),31,33-decaen-36-yl]oxy]-4-oxobutanoic acid
EINECS	Contact for details

Quality Control

Our Teicoplanin A2-3 is manufactured and tested under strict quality management systems. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research and development. Comprehensive testing includes identification, assay, and impurity profile analysis by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥95.0% (on anhydrous basis)
Water (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤3.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	<5.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.