Description

Poly(8-Bromodeoxyadenylic Acid) is a chemically modified oligonucleotide polymer where the 8-position of the adenine base is brominated. This specific modification is critical for advanced biochemical research, particularly in the study of nucleic acid structure, function, and interactions. It is primarily utilized by research institutions and biotechnology companies specializing in molecular biology, structural biology, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a specialized substrate or probe in enzymatic studies, particularly with polymerases and nucleases, to investigate reaction mechanisms and substrate specificity.
• Structural Studies: Serves as a model compound in X-ray crystallography and NMR spectroscopy to analyze the conformational impact of base halogenation on DNA/RNA duplex stability and geometry.
• Antisense & Aptamer Development: Acts as a modified building block in the synthesis of oligonucleotides for exploring enhanced binding affinity, nuclease resistance, and novel biological activities.
• Photochemical & Cross-linking Studies: The bromine atom provides a handle for photo-activation or further chemical derivatization, useful in cross-linking experiments to map biomolecular interactions.
• Material Science: Investigated for creating functionalized nucleic acid-based nanomaterials and conductive polymers with unique electronic properties.

Basic Information

Product Name	Poly(8-Bromodeoxyadenylic Acid)
CAS No.	90968-89-1
Molecular Formula	(C10H11BrN5O6P)n
Molecular Weight	Contact for details (Polymer)
Synonyms	Poly(8-Br-dA); Poly(8-bromodeoxyadenosine 5'-monophosphate); 8-Bromodeoxyadenylic Acid Homopolymer; Poly(8-Bromo-2'-deoxyadenylic acid); Poly(8-Br-2'-deoxyadenosine 5'-phosphate); 8-Bromo-dAMP Polymer; Brominated Polydeoxyadenylic Acid
EINECS	Contact for details

Quality Control

Our Poly(8-Bromodeoxyadenylic Acid) is produced and tested under stringent conditions to ensure batch-to-batch consistency and high purity for research applications. Quality is verified through a suite of analytical techniques including HPLC, UV-Vis spectroscopy, and gel electrophoresis. A comprehensive Certificate of Analysis (COA) detailing purity, molecular weight distribution, and bromine content is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (UV)	Complies
Purity (HPLC)	≥ 90% (Polymer)
Bromine Content	As per theoretical calculation
Solubility	Soluble in aqueous buffers, DMSO
Endotoxin Level	< 10 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.