Description

Deoxyadenylyl-Thymidylyl-Deoxyguanylyl-Deoxyguanosine is a defined-sequence oligonucleotide, specifically a tetramer, composed of deoxyadenosine, thymidine, and deoxyguanosine nucleotides. This compound is a critical building block and reference standard in molecular biology and genetic research. It is primarily utilized by biotechnology firms, pharmaceutical R&D departments, and academic research institutions engaged in nucleic acid chemistry, oligonucleotide synthesis, and the development of diagnostic assays or therapeutic oligonucleotides.

Application

• Oligonucleotide Synthesis: Serves as a key intermediate or reference standard in the solid-phase synthesis of longer DNA strands for research and therapeutic applications.
• Molecular Biology Research: Used as a primer, probe, or model compound in PCR, sequencing, hybridization studies, and other genetic analysis techniques.
• Pharmaceutical Development: Acts as a starting material or impurity standard in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.
• Diagnostic Assay Development: Employed in the design and calibration of diagnostic kits for genetic testing and pathogen detection.
• Biochemical Studies: Utilized to study DNA-protein interactions, enzyme kinetics (e.g., with nucleases or polymerases), and nucleic acid structure.
• Quality Control: Functions as a system suitability test compound or an analytical reference standard in QC laboratories for oligonucleotide manufacturers.

Basic Information

Item	Details
Product Name	Deoxyadenylyl-Thymidylyl-Deoxyguanylyl-Deoxyguanosine
CAS No.	90730-73-7
Molecular Formula	C41H50N15O23P3
Molecular Weight	1194.83 g/mol
Synonyms	d(ApTpGpG); d(A-T-G-G); Deoxyadenylyl-(3'→5')-thymidylyl-(3'→5')-deoxyguanylyl-(3'→5')-deoxyguanosine; DNA Tetramer A-T-G-G; Oligodeoxynucleotide d(ATGG); 5'-d(ATGG)-3'; Adenine-Thymine-Guanine-Guanine Tetramer
EINECS	Contact for details

Quality Control

Our oligonucleotide products are manufactured under strict quality systems. Each batch of Deoxyadenylyl-Thymidylyl-Deoxyguanylyl-Deoxyguanosine undergoes comprehensive analytical testing, including HPLC for purity assessment and mass spectrometry (MS) for identity confirmation, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Extinction Coefficient	Provided on COA
Molecular Weight	1194.83 g/mol (Theoretical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.