Description

Nafcillin Sodium Salt CAS NO 985-16-0 is a semisynthetic, β-lactamase-resistant penicillin antibiotic in its sodium salt form. This compound is critical for pharmaceutical research and development, particularly in the study of antibiotic resistance and the formulation of sterile injectable products. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in antimicrobial agent development and quality control testing.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of sterile injectable antibiotic preparations for clinical use.
• Microbiological Research: Serves as a reference standard and selective agent in studies of penicillinase-producing Staphylococcus aureus and other resistant bacteria.
• Quality Control & Analytical Testing: Employed as a certified reference material (CRM) for HPLC, UV, and microbiological assay calibration in pharmaceutical quality assurance labs.
• Antibiotic Susceptibility Testing: Used to prepare discs or solutions for in vitro antimicrobial susceptibility testing (AST) in clinical diagnostics.
• Biochemical Studies: Utilized in research investigating the mechanisms of β-lactam antibiotic action and bacterial cell wall synthesis inhibition.
• Veterinary Medicine: Applied in the development of treatments for bacterial infections in animals.

Basic Information

Product Name	Nafcillin Sodium Salt
CAS No.	985-16-0
Molecular Formula	C21H21N2NaO5S
Molecular Weight	436.46 g/mol
Synonyms	Nafcillin Sodium; Sodium Nafcillin; 6-(2-Ethoxy-1-naphthamido)penicillanic Acid Sodium Salt; Wy-3277; Unipen; Nafcil; Nallpen; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-ethoxy-1-naphthoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt
EINECS	213-588-9

Quality Control

Our Nafcillin Sodium Salt is manufactured and tested under a strict quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, purity, assay, and related substances. We support compliance with cGMP and relevant pharmacopeial guidelines (e.g., USP, EP) for API starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
pH (1% Solution)	5.5 - 7.5
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 1.0%
Bacterial Endotoxins	< 0.25 EU/mg (where applicable)
Sterility (for sterile grade)	Passes test (where applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.