Description

Penamecillin CAS NO 983-85-7 is a penicillin antibiotic prodrug, specifically the benzathine salt of penicillin G. This chemical form is valued for its enhanced stability and prolonged action compared to the parent compound, making it a critical intermediate in pharmaceutical manufacturing. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for the production of long-acting injectable antibiotic formulations.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key starting material for the synthesis of benzathine penicillin G, a long-acting antibiotic.
• Pharmaceutical Formulations: Used in the development and production of injectable depot formulations for sustained-release antibiotic therapy.
• Veterinary Medicine: Employed in the manufacture of long-acting antibiotic treatments for livestock and companion animals.
• Research & Development: Serves as a reference standard and building block in microbiological and pharmacological research for novel antibiotic agents.
• Bulk Drug Substance: Supplied to contract manufacturing organizations (CMOs) for large-scale production of finished dosage forms.

Basic Information

Product Name	Penamecillin
CAS No.	983-85-7
Molecular Formula	C32H36N4O6S2
Molecular Weight	636.78 g/mol
Synonyms	Benzathine Penicillin G; Penicillin G Benzathine; N,N'-Dibenzylethylenediamine bis(benzylpenicillin); Benzylpenicillin Benzathine; DBED Penicillin G; Longicil; Bicillin; Permapen; Penadur; Benzetacil; Tardocillin
EINECS	213-572-8

Quality Control

Our Penamecillin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can support compliance with relevant pharmacopoeial standards (e.g., USP, EP, BP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light and moisture to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details
Microbial Limits	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.