Description

Penicillin G Calcium is the calcium salt of benzylpenicillin, a fundamental β-lactam antibiotic. This compound is critical for ensuring the stability and bioavailability of the active pharmaceutical ingredient in various formulations. It is an essential raw material for manufacturers in the pharmaceutical and veterinary medicine industries, serving as a key intermediate in the production of injectable antibiotics. Its reliable quality is paramount for meeting stringent global pharmacopeial standards.

Application

• Pharmaceutical API Intermediate: Primary use as a starting material or intermediate in the synthesis of sterile injectable penicillin formulations.
• Veterinary Medicine Production: Used in the manufacture of antibiotics for treating bacterial infections in livestock and companion animals.
• Bulk Drug Substance: Sourced by contract manufacturing organizations (CMOs) for the production of finished dosage forms under cGMP.
• Research & Development: Utilized in microbiological labs and pharmaceutical R&D for antibiotic stability studies and new formulation development.
• Reference Standard: Serves as a chemical reference standard for quality control and analytical method validation in regulatory testing.

Basic Information

Product Name	Penicillin G Calcium
CAS No.	973-53-5
Molecular Formula	C16H18CaN2O4S2
Molecular Weight	406.46 g/mol
Synonyms	Benzylpenicillin Calcium Salt; Calcium Benzylpenicillin; Penicillin G Calcium Salt; Crystalline Penicillin G Calcium; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid calcium salt; Benzylpenicillin Calcium; Calcium Penicillin G; Crystapen
EINECS	213-560-5

Quality Control

Our Penicillin G Calcium is manufactured and tested to meet high-purity standards suitable for pharmaceutical use. Quality is assured through a comprehensive battery of tests including identification, assay, and impurity profiling. We provide full traceability and support compliance with major pharmacopeias. Certificates of Analysis (COA) documenting compliance with specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	95.0% - 102.0% (on anhydrous basis)
pH (aqueous solution)	5.5 - 7.5
Water (Karl Fischer)	≤ 3.0%
Specific Optical Rotation	+285° to +310°
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.