Description

Benzthiazide is a potent thiazide-class diuretic agent, widely recognized for its role in managing hypertension and edema. Its primary value lies in its reliable pharmacological action, which promotes sodium and water excretion to reduce fluid volume and blood pressure. This compound is essential for pharmaceutical manufacturers and research institutions developing cardiovascular medications and studying renal physiology.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key component in the formulation of prescription diuretic and antihypertensive medications.
• Pharmaceutical Research & Development: Serves as a critical reference standard and building block in the discovery and development of new cardiovascular and renal therapies.
• Clinical Pharmacology Studies: Used in bioequivalence testing and pharmacokinetic research to understand drug behavior in the body.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods to ensure product quality.

Basic Information

Product Name	Benzthiazide
CAS No.	91-33-8
Molecular Formula	C₁₅H₁₄ClN₃O₄S₃
Molecular Weight	431.94 g/mol
Synonyms	3-[(Benzylthio)methyl]-6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide; Benzthiazide; P 1393; Aquatag; Exna; Fovane; Hydrex; Proaqua; Urazide; Benzthiazidum
EINECS	202-058-4

Quality Control

Our Benzthiazide is manufactured under strict quality management systems, with specifications designed to meet the rigorous demands of the pharmaceutical industry. We provide comprehensive analytical data to support regulatory filings, including identification, purity, and impurity profiles. A Certificate of Analysis (COA) is supplied with each batch, detailing results against specifications for parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.