Description

2'-Carboethoxy-3-(3,4,5-Trifluorophenyl)Propiophenone is a high-value fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. Its precise molecular architecture, featuring both a carboethoxy and a trifluorophenyl moiety, makes it a critical building block for the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for constructing novel molecular scaffolds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl group improves lipophilicity and bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent for creating specialty polymers with unique optical or electronic properties.
• Ligand and Catalyst Development: Employed in organic chemistry research for constructing complex chelating ligands used in asymmetric catalysis.
• Fluorine Chemistry Studies: A valuable reference compound for academic and industrial research into the effects of polyfluorination on reaction pathways and molecular properties.

Basic Information

Product Name	2'-Carboethoxy-3-(3,4,5-Trifluorophenyl)Propiophenone
CAS No.	898777-76-9
Molecular Formula	C18H15F3O3
Molecular Weight	336.31 g/mol
Synonyms	Ethyl 2-(3-oxo-3-phenylpropyl)-3,4,5-trifluorobenzoate; 3,4,5-Trifluoro-β-oxobenzenepropanoic acid ethyl ester; 2'-Ethoxycarbonyl-3-(3,4,5-trifluorophenyl)propiophenone; 898777-76-9; Propiophenone, 2'-carboethoxy-3-(3,4,5-trifluorophenyl)-; Ethyl 3-(3,4,5-trifluorophenyl)-3-oxopropanecarboxylate (related structure)
EINECS	Contact for details

Quality Control

Every batch of 2'-Carboethoxy-3-(3,4,5-Trifluorophenyl)Propiophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for pharmaceutical and advanced chemical synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and MS. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.