Description

2-(1,1-Difluoroethyl)Benzoic Acid is a specialized fluorinated aromatic carboxylic acid building block of significant interest in advanced organic synthesis. This compound matters for its unique structural motif, which combines a benzoic acid core with a difluoroethyl group, offering distinct electronic and steric properties for molecular design. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly where fluorine substitution is used to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and pesticides, where the difluoroethyl group can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and advanced organic materials with tailored properties.
• Fluorine Chemistry Research: An important building block in academic and industrial laboratories studying the effects of fluorine introduction on molecular conformation and reactivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	2-(1,1-Difluoroethyl)Benzoic Acid
CAS No.	892390-46-4
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	2-(1,1-Difluoroethyl)benzoic acid; Benzoic acid, 2-(1,1-difluoroethyl)-; α,α-Difluoro-2-methylbenzenacetic acid; 2-(Difluoroethyl)benzoic acid; 2-(1,1-Difluoroethyl)benzenecarboxylic acid; o-(1,1-Difluoroethyl)benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(1,1-Difluoroethyl)Benzoic Acid is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.