Description

2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid is a high-value, multifunctional chemical building block that combines a benzoic acid moiety with a boronic ester pinacol group. This compound is essential for facilitating advanced cross-coupling reactions, enabling the efficient synthesis of complex molecular architectures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated biphenyl and heterobiaryl compounds, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used to create novel fluorinated herbicides, fungicides, and insecticides, where the fluorine atom and boronic ester group enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the conjugated system can be extended via cross-coupling.
• Chemical Biology Probes: Utilized to create fluorinated molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid
CAS No.	891843-32-6
Molecular Formula	C13H16BFO4
Molecular Weight	266.08 g/mol
Synonyms	2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 2-Fluoro-6-(pinacolatoboryl)benzoic acid; 6-Carboxy-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; B-(6-Carboxy-2-fluorophenyl)boronic acid pinacol ester; 891843-32-6; 2-Fluoro-6-pinacolatoborylbenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent lot-to-lot performance critical for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.