Description

Bardoxolone is a potent synthetic triterpenoid and a well-characterized activator of the Nrf2 (Nuclear factor erythroid 2-related factor 2) signaling pathway. This compound matters for its significant role as a research tool in studying oxidative stress, inflammation, and related disease mechanisms. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for conditions like chronic kidney disease, pulmonary arterial hypertension, and cancer.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in preclinical and clinical studies.
• Mechanistic Biology Studies: Used to investigate the Nrf2-Keap1 pathway, cellular defense mechanisms against oxidative stress, and anti-inflammatory responses.
• Drug Discovery Programs: Serves as a lead compound or pharmacophore model for developing new therapeutic agents targeting inflammatory and fibrotic diseases.
• Biochemical Assay Development: Employed as a control compound in high-throughput screening (HTS) assays to identify novel Nrf2 activators or inhibitors.
• Academic Research: Utilized in university and institutional labs to explore its effects on mitochondrial function, metabolism, and cytoprotection.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	Bardoxolone
CAS No.	890707-28-5
Molecular Formula	C31H38O4
Molecular Weight	474.63 g/mol
Synonyms	Bardoxolone; CDDO; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid; RTA 402; NSC 713200; TP-235; 2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid; Olean-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-
EINECS	Contact for details

Quality Control

Our Bardoxolone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.