Description

2-(Dansylsulfonamido)Ethyl-3-(Hydrazinocarboxy)Ethyl Disulfide is a specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation and labeling applications. This compound is engineered to provide researchers with a powerful tool for creating stable, fluorescently tagged biomolecular complexes. It is essential for scientists and manufacturers in the fields of proteomics, diagnostics, and pharmaceutical research who require precise and reliable conjugation chemistry. The product offers a unique combination of a dansyl fluorophore for detection and a hydrazine functionality for site-specific coupling to carbonyl groups.

Application

• Fluorescent Labeling of Antibodies and Proteins: Site-specific conjugation via hydrazone bond formation for flow cytometry, immunofluorescence, and microscopy.
• Bioconjugation for Diagnostic Assay Development: Creating stable, fluorescent probes for ELISA, lateral flow assays, and other diagnostic platforms.
• Crosslinking in Structural Biology: Studying protein-protein interactions and mapping molecular structures through controlled crosslinking.
• Proteomics Research: Labeling glycoproteins or other carbonyl-containing biomolecules for analysis via gel electrophoresis or mass spectrometry.
• Drug Delivery System Conjugation: Attaching targeting ligands or fluorescent tags to nanoparticles or polymer carriers for tracking and specificity.
• Biomaterial Surface Functionalization: Modifying surfaces with fluorescent markers for cell adhesion studies or biosensor development.

Basic Information

Product Name	2-(Dansylsulfonamido)Ethyl-3-(Hydrazinocarboxy)Ethyl Disulfide
CAS No.	887354-22-5
Molecular Formula	C19H28N4O5S3
Molecular Weight	488.64 g/mol
Synonyms	Dansyl Hydrazine Disulfide Crosslinker; 5-(Dimethylamino)naphthalene-1-sulfonyl-2-aminoethyl-3-(hydrazinecarbonyl)ethyl disulfide; N-[2-[[2-[(5-Dimethylamino-1-naphthalenesulfonyl)amino]ethyl]dithio]ethyl]hydrazinecarboxamide; Dansyl C2-SS-C2 Hydrazide; Heterobifunctional Dansyl-Hydrazine Crosslinker; Dns-AE-SS-AH
EINECS	Contact for details

Quality Control

Our production of 2-(Dansylsulfonamido)Ethyl-3-(Hydrazinocarboxy)Ethyl Disulfide adheres to stringent quality protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is easily oxidized and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. For optimal performance, use immediately after preparation of working solutions.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in aqueous buffers
Functional Group Integrity	≥ 90% (by hydrazine assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.