Description

4-Methyl-3-(trifluoromethyl)cinnamic acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its unique structure, featuring both a trifluoromethyl group and a cinnamic acid backbone, makes it invaluable for modulating the physicochemical properties of target molecules, particularly in enhancing metabolic stability and lipophilicity. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated aromatic motifs into novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers used in the production of high-performance electronic display materials.
• Organic Synthesis Building Block: Employed in Suzuki-Miyaura coupling, Heck reactions, and other cross-coupling methodologies to create complex, fluorinated molecular architectures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on fluorine chemistry and structure-activity relationship (SAR) studies.
• Peptide Mimetics: The cinnamic acid moiety can be utilized in the design and synthesis of peptidomimetics and protease inhibitors.

Basic Information

Product Name	4-Methyl-3-(Trifluoromethyl)Cinnamic Acid
CAS No.	886498-02-8
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	(E)-3-[4-Methyl-3-(trifluoromethyl)phenyl]acrylic acid; 3-(4-Methyl-3-(trifluoromethyl)phenyl)-2-propenoic acid; 4-Methyl-3-trifluoromethylcinnamic Acid; (E)-4-Methyl-α-(trifluoromethyl)cinnamic Acid; 2-Propenoic acid, 3-[4-methyl-3-(trifluoromethyl)phenyl]-, (2E)-; 4-Methyl-3-(trifluoromethyl)benzeneacrylic acid; 886498-02-8; 4-Methyl-3-(trifluoromethyl)trans-cinnamic acid
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(trifluoromethyl)cinnamic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.