Description

2-Fluoro-5-(trifluoromethoxy)benzoic acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the design of next-generation herbicides, fungicides, and insecticides, where the fluorine motifs enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Used in the synthesis of fluorinated aromatic components for high-performance liquid crystal displays (LCDs) due to its influence on dielectric anisotropy and thermal stability.
• Polymer Chemistry: Incorporated as a monomer or modifier to produce specialty polymers with enhanced chemical resistance, thermal properties, and surface characteristics.
• Organic Electronics: Acts as a building block for electron-transport materials and semiconductors used in organic light-emitting diodes (OLEDs) and photovoltaic cells.
• Chemical Research: Employed in academic and industrial R&D for studying structure-activity relationships (SAR) and developing novel synthetic methodologies involving fluorinated arenes.

Basic Information

Product Name	2-Fluoro-5-(trifluoromethoxy)benzoic Acid
CAS No.	886497-85-4
Molecular Formula	C8H4F4O3
Molecular Weight	224.11 g/mol
Synonyms	2-Fluoro-5-(trifluoromethoxy)benzoic acid; 5-(Trifluoromethoxy)-2-fluorobenzoic acid; Benzoic acid, 2-fluoro-5-(trifluoromethoxy)-; 886497-85-4; 2-Fluoro-α,α,α-trifluoro-p-anisic acid; 2-Fluoro-5-trifluoromethoxybenzoic acid
EINECS	Contact for details

Quality Control

Every batch of our 2-Fluoro-5-(trifluoromethoxy)benzoic acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.