Description

1-(4-Trifluoromethyl-Phenyl)-Cyclopropanecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its cyclopropane carboxylic acid core and trifluoromethylphenyl substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific steric and electronic properties. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material science sectors for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug molecules, especially in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Used in organometallic chemistry and catalysis research to create novel ligands for asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals, where the rigid cyclopropane ring contributes to unique material properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	1-(4-Trifluoromethyl-Phenyl)-Cyclopropanecarboxylic Acid
CAS No.	886366-13-8
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	[4-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid; 1-[4-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid; 4-(Trifluoromethyl)benzenepropanoic acid, α,α-cyclopropane-; Cyclopropanecarboxylic acid, 1-[4-(trifluoromethyl)phenyl]-; α-(4-Trifluoromethylphenyl)cyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(4-Trifluoromethyl-Phenyl)-Cyclopropanecarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.