Description

1-(2-Trifluoromethyl-Phenyl)-Cyclopropanecarboxylic Acid is a high-value, multi-functional chemical intermediate characterized by its cyclopropane ring and trifluoromethylphenyl moiety. This compound is essential for synthesizing advanced molecules where the introduction of a rigid cyclopropane structure and fluorine atoms is required to modulate biological activity, metabolic stability, and physicochemical properties. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Material Science Precursor: Serves as a starting material for advanced polymers and liquid crystals, contributing unique steric and electronic properties to the final material.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex organic frameworks via reactions involving the carboxylic acid and the strained cyclopropane ring.
• Fluorine Chemistry Research: A valuable compound for studying structure-activity relationships (SAR) in fluorine-containing molecules due to its distinct substitution pattern.

Basic Information

Product Name	1-(2-Trifluoromethyl-Phenyl)-Cyclopropanecarboxylic Acid
CAS No.	886366-06-9
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	2-(Trifluoromethyl)phenylcyclopropanecarboxylic Acid; 1-[2-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 1-[2-(trifluoromethyl)phenyl]-; α-(2-Trifluoromethylphenyl)cyclopropanecarboxylic Acid; 1-(2-Trifluoromethylphenyl)cyclopropanecarboxylic acid; 886366-06-9; 1-(o-Trifluoromethylphenyl)cyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our production of 1-(2-Trifluoromethyl-Phenyl)-Cyclopropanecarboxylic Acid adheres to stringent in-process controls and final batch release testing to ensure consistent purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality management system is designed to meet the exacting standards required for advanced chemical intermediates in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.