Description

4-Biphenyl-3',5'-Difluoro-Acetic Acid is a high-purity fluorinated biphenyl acetic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the precise introduction of fluorine atoms and a carboxylic acid functional group onto a biphenyl scaffold, enabling fine-tuning of molecular properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where enhanced metabolic stability and bioavailability are required.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and plant growth regulators where the fluorinated biphenyl moiety imparts improved activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and electron-transport/hole-blocking materials in organic light-emitting diodes (OLEDs).
• Polymer Science: Acts as a monomer or modifier for creating specialty polymers with enhanced thermal stability, chemical resistance, and specific optical properties.
• Chemical Biology & Proteomics: Useful as a linker or tagging agent in the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Material Science Research: Employed in the synthesis of metal-organic frameworks (MOFs) and other advanced porous materials for catalysis and sensing applications.

Basic Information

Product Name	4-Biphenyl-3',5'-Difluoro-Acetic Acid
CAS No.	886363-26-4
Molecular Formula	C14H10F2O2
Molecular Weight	248.23 g/mol
Synonyms	[4-(3,5-Difluorophenyl)phenyl]acetic acid; 2-[4-(3,5-Difluorophenyl)phenyl]acetic Acid; 3',5'-Difluoro[1,1'-biphenyl]-4-acetic Acid; 4-Biphenyl-3',5'-difluoroacetic Acid; (4'-Biphenyl-3,5-difluoro)acetic Acid; Biphenyl-3',5'-difluoro-acetic Acid; NSC 886363
EINECS	Contact for details

Quality Control

Every batch of 4-Biphenyl-3',5'-Difluoro-Acetic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.