Description

(S)-Gna-C(Bz)-Phosphoramidite is a high-purity, chiral phosphoramidite monomer, a critical building block in the automated synthesis of oligonucleotides. This compound matters for its role in introducing modified nucleosides, enabling the creation of advanced therapeutic nucleic acids with enhanced stability and targeting properties. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries developing antisense oligonucleotides, siRNA, and other novel genetic medicines.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite reagent for the automated synthesis of DNA/RNA strands.
• Antisense Oligonucleotide (ASO) Development: For the production of therapeutic oligonucleotides targeting specific mRNA sequences.
• siRNA and miRNA Synthesis: Enables the incorporation of modified bases to improve nuclease resistance and pharmacokinetic profiles.
• Pharmaceutical R&D: Used in research laboratories for developing novel nucleic acid-based therapeutics and diagnostics.
• Probe and Primer Synthesis: For creating labeled or modified oligonucleotides used in genetic testing and molecular biology.
• API Intermediate: Serves as a critical raw material in the Good Manufacturing Practice (GMP) production of oligonucleotide active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	(S)-Gna-C(Bz)-Phosphoramidite
CAS No.	885322-06-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-[(2R,3R,4R,5R)-5-[Bis(4-methoxyphenyl)(phenyl)methoxy]-4-[(benzoyl)amino]-3-(2-cyanoethoxy)phosphanyloxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione; (S)-Guanosine-C(Bz) Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-benzoyl-2'-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dG-CE Phosphoramidite (Bz protected); N2-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
EINECS	Contact for details

Quality Control

Our (S)-Gna-C(Bz)-Phosphoramidite is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance in pharmaceutical R&D and production environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.