Description

Anle138B is a high-purity, small molecule compound of significant interest in advanced biomedical research. This product is valued for its specific activity as an inhibitor of α-synuclein aggregation, a key pathological target. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in neurodegenerative disease studies, particularly for Parkinson's disease and related synucleinopathies.

Application

• Neurodegenerative Disease Research: A key tool compound for investigating the pathogenesis and potential treatment of Parkinson's disease.
• α-Synuclein Aggregation Studies: Used in in vitro and cellular assays to inhibit and monitor the formation of toxic protein oligomers and fibrils.
• Preclinical Drug Development: Serves as a lead compound or reference standard in the discovery and optimization of novel therapeutic agents.
• Biochemical Pathway Analysis: Employed to elucidate cellular mechanisms related to protein misfolding and cellular toxicity.
• Animal Model Studies: Utilized in preclinical research to evaluate efficacy and pharmacokinetics in relevant disease models.

Basic Information

Product Name	Anle138B
CAS No.	882697-00-9
Molecular Formula	C23H21N3O3
Molecular Weight	387.43 g/mol
Synonyms	3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole; Anle-138b; Nilotinib Derivative; α-Synuclein Aggregation Inhibitor; 5-(3-Bromophenyl)-3-(1,3-benzodioxol-5-yl)-1H-pyrazole
EINECS	Contact for details

Quality Control

Our Anle138B is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and NMR/LC-MS for structural identity, to ensure it meets the exacting standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.