Description

5-(2,4-Difluorophenyl)-Furan-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its difluorophenyl and furan carboxylic acid motifs. This compound matters for its critical role as a versatile intermediate in the synthesis of complex molecules, particularly in the pharmaceutical sector where its structure imparts desirable metabolic stability and binding affinity. It is primarily needed by research chemists and process development scientists in pharmaceutical, agrochemical, and advanced material industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors, anti-inflammatory, and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the bioactivity of the fluorinated aromatic system.
• Material Science Research: Serves as a precursor for organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Employed as a building block for activity-based probes and molecular tags due to its reactive carboxylic acid group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for scale-up and GMP production of client-specific target molecules.
• Academic & Industrial R&D: Fundamental research reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	5-(2,4-Difluorophenyl)-Furan-2-Carboxylic Acid
CAS No.	874801-40-8
Molecular Formula	C11H6F2O3
Molecular Weight	224.16 g/mol
Synonyms	2,4-Difluoro-5-(2-furoyl)benzene; 5-(2,4-Difluorophenyl)-2-furancarboxylic Acid; 2-Furoic acid, 5-(2,4-difluorophenyl)-; 874801-40-8; 5-(2,4-Difluorophenyl)furan-2-carboxylic acid; 2-Furancarboxylic acid, 5-(2,4-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 5-(2,4-Difluorophenyl)-Furan-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.