Description

(Lys(Me)24)-Histone H3 (1-21) CAS NO 873215-01-1 is a chemically modified peptide fragment corresponding to the N-terminal tail of histone H3, specifically dimethylated at lysine 24. This compound serves as a critical biochemical tool for studying epigenetic regulation, chromatin dynamics, and enzyme-substrate interactions. It is essential for researchers and developers in the fields of epigenetics, drug discovery, and molecular biology who require high-purity, well-characterized substrates for assay development and mechanistic studies.

Application

• Enzyme Activity Assays: Used as a specific substrate for studying the activity and inhibition of histone methyltransferases (HMTs) and demethylases (KDMs).
• Biochemical Research: Essential for in vitro studies investigating the role of H3K24 methylation in chromatin remodeling and gene expression.
• Antibody Validation: Serves as a positive control antigen for validating the specificity of antibodies raised against methylated histone marks.
• Drug Screening Platforms: Incorporated into high-throughput screening (HTS) assays to identify novel modulators of epigenetic targets.
• Peptide Array & Microarray Development: Used in the synthesis of peptide arrays for profiling protein-protein and protein-nucleic acid interactions.
• Standards & Calibrants: Acts as a quantitative standard in mass spectrometry-based proteomics for epigenetic biomarker discovery.

Basic Information

Product Name	(Lys(Me)24)-Histone H3 (1-21)
CAS No.	873215-01-1
Molecular Formula	C108H186N36O28
Molecular Weight	Contact for details
Synonyms	Histone H3 (1-21), Lys24-dimethylated; H3(1-21)K24me2; ARTKQTARKSTGGKAPRKQLA-K(Me2); N-terminal H3 peptide (dimethyl Lys24); Acetylated N-terminal H3 peptide (K24me2); Epigenetic Peptide Substrate; Histone Peptide H3K24me2; Chromatin Research Peptide
EINECS	Contact for details

Quality Control

Every batch of (Lys(Me)24)-Histone H3 (1-21) is produced and analyzed under stringent quality protocols to ensure identity, purity, and batch-to-batch consistency suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing HPLC purity, MS confirmation, and amino acid analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.