Description

N2-Methyl-2'-Deoxyguanosine is a chemically modified nucleoside derivative where a methyl group is attached to the exocyclic amino group of the guanine base. This specific modification is crucial for biochemical research, particularly in the study of DNA damage, repair mechanisms, and epigenetic regulation. It serves as a vital reference standard and building block for researchers and manufacturers in the fields of pharmaceutical development, molecular diagnostics, and academic biochemistry.

Application

• Biochemical Research Standard: Used as a high-purity reference material for the quantification and identification of methylated DNA adducts in toxicology and cancer research.
• Pharmaceutical Intermediate: Acts as a key synthon in the development of novel nucleoside-based therapeutics, including antiviral and anticancer agents.
• Epigenetics Studies: Essential for investigating the role of non-canonical DNA methylation in gene expression and cellular processes.
• Diagnostic Kit Development: Employed in the formulation of calibration standards for LC-MS/MS and HPLC assays designed to detect DNA damage biomarkers.
• Enzyme Substrate/Inhibitor Studies: Utilized to study the specificity and kinetics of DNA repair enzymes like alkyltransferases.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite precursor for the solid-phase synthesis of probes and primers with specific functionalities.

Basic Information

Product Name	N2-Methyl-2'-Deoxyguanosine
CAS No.	19916-77-9
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	2'-Deoxy-N2-methylguanosine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-2-methylamino-6-oxo-1,6-dihydro-9H-purin-9-one; N2-Methyl-2'-deoxyguanosine; N2-Methyl-dG; 2-Methylamino-2'-deoxyguanosine; 2'-Deoxy-N(2)-methylguanosine; dG(N2-Me)
EINECS	Contact for details

Quality Control

Every batch of N2-Methyl-2'-Deoxyguanosine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.