Description

N6-Methyl-2'-Deoxy-Adenosine is a modified nucleoside where a methyl group is attached to the N6 position of the adenine base, a structural analog of the fundamental building block 2'-deoxyadenosine. This specific modification is of significant interest in biochemical research, particularly in the study of epigenetic regulation, DNA damage, and nucleic acid metabolism. It serves as a critical reference standard, synthetic intermediate, and research reagent for pharmaceutical R&D and academic laboratories focused on nucleoside chemistry and molecular biology.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, LC-MS) of nucleoside-based drugs and metabolites in quality control and pharmacokinetic studies.
• Biochemical Research Reagent: Essential for studying DNA methylation analogs, enzyme-substrate interactions (e.g., with methyltransferases), and nucleic acid repair mechanisms.
• Synthetic Intermediate: Serves as a key building block in the chemical synthesis of more complex nucleoside analogs, prodrugs, and oligonucleotides for therapeutic development.
• Epigenetics & Molecular Biology: Applied in research exploring epigenetic markers, DNA damage responses, and the biological activity of modified nucleosides.
• Antiviral & Anticancer Drug Development: Investigated as a precursor or model compound in the R&D of novel nucleoside analogs targeting viral replication or cellular proliferation.

Basic Information

Product Name	N6-Methyl-2'-Deoxy-Adenosine
CAS No.	2002-35-9
Molecular Formula	C11H15N5O3
Molecular Weight	265.27 g/mol
Synonyms	N6-Methyl-2'-deoxyadenosine; N(6)-Methyl-2'-deoxyadenosine; 6-Methylamino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine; 2'-Deoxy-N6-methyladenosine; 6-(Methylamino)-9-(2-deoxy-β-D-ribofuranosyl)-9H-purine; N6-Methyl-deoxyadenosine; m6dA; N6-Methyladenine Deoxyriboside
EINECS	Contact for details

Quality Control

Our N6-Methyl-2'-Deoxy-Adenosine is produced and tested under stringent quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.