Description

Cpi-455 is a potent and selective small molecule inhibitor of the BET (bromodomain and extra-terminal) family of proteins, specifically targeting the second bromodomain (BD2). This compound is a critical research tool for investigating epigenetic regulation and its role in various disease pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, immunology, and inflammatory disease studies. The product, identified by CAS NO 1628208-23-0, is supplied as a high-purity biochemical for preclinical and discovery applications.

Application

• Epigenetics Research: A key reagent for studying BET protein function and bromodomain-acetylated lysine interactions.
• Oncology Drug Discovery: Used in target validation and mechanism-of-action studies for cancers where BET proteins play a role, such as leukemia and solid tumors.
• Immunology & Inflammation Studies: Investigates the modulation of gene expression in immune cells for potential therapeutic applications in autoimmune diseases.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) and in vitro assays.
• Cell Signaling Pathway Analysis: Helps elucidate the downstream effects of BET inhibition on critical cellular processes.
• Preclinical Pharmacology: Supports in vivo efficacy and pharmacokinetic/pharmacodynamic (PK/PD) studies in animal models.

Basic Information

Product Name	Cpi-455
CAS No.	1628208-23-0
Molecular Formula	C₂₅H₂₈N₄O₄
Molecular Weight	448.51 g/mol
Synonyms	CPI-455; CPI455; (R)-CPI-455; PFI-5; (R)-PFI-5; (R)-N-(4-(2-(4-Chlorophenyl)-2-methyl-1-propanoyl)piperazin-1-yl)phenyl)-2-methyl-2-(methylsulfonyl)propanamide; BET inhibitor CPI-455; BD2-Selective BET Inhibitor
EINECS	Contact for details

Quality Control

Our Cpi-455 is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.