Description

Gsk-J4 Hydrochloride is a potent and selective chemical probe targeting histone demethylases, specifically the H3K27me3/me2-demethylase subfamily. This compound is critical for epigenetic research, enabling the precise study of gene regulation and chromatin remodeling processes. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, neurology, and developmental biology.

Application

• Epigenetics Research: Used as a selective inhibitor to study the role of specific histone demethylases (e.g., JMJD3, UTX) in cellular differentiation and disease states.
• Oncology Studies: Investigates the function of histone modifications in cancer cell proliferation, metastasis, and potential therapeutic targeting.
• Neuroscience Research: Explores the impact of epigenetic regulation on neural development, plasticity, and neurodegenerative conditions.
• Stem Cell Biology: Aids in understanding how epigenetic modifiers control pluripotency and cell fate decisions.
• Biochemical Assay Development: Serves as a reference standard in high-throughput screening and enzymatic activity assays.
• Preclinical Drug Discovery: Functions as a lead compound or tool molecule for validating novel targets in epigenetic pathways.

Basic Information

Product Name	Gsk-J4 Hydrochloride
CAS No.	1797983-09-5
Molecular Formula	C₂₄H₂₉ClN₄O₃ • HCl
Molecular Weight	485.88 g/mol
Synonyms	GSK-J4 HCl; (E)-N-((1-Methylpyrrolidin-2-yl)methyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)acrylamide hydrochloride; GSK J4 HCl; JMJD3/UTX Inhibitor GSK-J4 hydrochloride; GSKJ4 HCl; UNC-0638 (related compound); Histone Demethylase Inhibitor GSK-J4 HCl
EINECS	Contact for details

Quality Control

Our Gsk-J4 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.