Description

5-Hydroxymethylcytosine is a naturally occurring, modified form of cytosine that plays a pivotal role in the epigenetic regulation of gene expression. This compound is essential for researchers and developers in the life sciences, serving as a critical biomarker for DNA demethylation processes. It is primarily utilized in advanced research applications within pharmaceutical development, molecular biology, and epigenetics, where precise and high-purity biochemicals are required.

Application

• Epigenetics Research: A key substrate and biomarker for studying active DNA demethylation pathways and gene regulation.
• Pharmaceutical R&D: Used in the development of novel therapeutics targeting epigenetic modifications in oncology and neurology.
• Diagnostic Assay Development: Serves as a standard or reference compound in kits for detecting epigenetic changes associated with diseases.
• Biochemical Synthesis: Acts as a building block or intermediate in the synthesis of nucleosides, nucleotides, and related probes.
• Academic Research: Fundamental tool for universities and research institutes investigating cell differentiation, development, and aging.
• Quality Control Standards: Used as a certified reference material (CRM) to validate analytical methods in testing laboratories.

Basic Information

Product Name	5-Hydroxymethylcytosine
CAS No.	1123-95-1
Molecular Formula	C5H7N3O2
Molecular Weight	141.13 g/mol
Synonyms	5-Hydroxymethylcytosine; 5-HMC; hm5C; 4-Amino-2-oxo-1(2H)-pyrimidine-5-methanol; 5-(Hydroxymethyl)cytosine; 5-Hydroxymethyl-cytosine; Cytosine, 5-hydroxymethyl-; NSC 266046
EINECS	214-377-7

Quality Control

Our 5-Hydroxymethylcytosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.