Description

o-Isobutyryl Naltrexone is a key pharmaceutical intermediate and chemical building block. This compound is of significant interest for research and development in medicinal chemistry, particularly for the synthesis of novel opioid receptor modulators. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of naltrexone derivatives and other opioid antagonists.
• Medicinal Chemistry Research: Used as a building block for structure-activity relationship (SAR) studies targeting opioid receptors.
• Process Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of API manufacturing processes.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Utilized in studies investigating the biochemical pathways and mechanisms of opioid receptor ligands.

Basic Information

Item	Detail
Product Name	o-Isobutyryl Naltrexone
CAS No.	861238-38-2
Molecular Formula	C26H31NO5
Molecular Weight	437.53 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one o-isobutyrate; 6-O-(2-Methylpropanoyl)naltrexone; Naltrexone 6-O-isobutyrate; o-Isobutyrylnaltrexone; Naltrexone isobutyrate ester
EINECS	Contact for details

Quality Control

Our o-Isobutyryl Naltrexone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.