Description

8S-Cabergoline CAS NO 856676-33-0 is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is critical for research and development in the pharmaceutical industry, particularly for projects involving dopamine receptor agonists. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories requiring a reliable and well-characterized chemical entity for synthesis, method development, and quality control.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting neurological and endocrine disorders.
• Reference Standard: Used for analytical method validation, calibration of equipment (e.g., HPLC, LC-MS), and quality control testing in pharmaceutical manufacturing.
• Research & Development: Essential for preclinical and clinical research studies investigating dopaminergic pathways and related therapeutic areas.
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for the production of cabergoline-related compounds.
• Regulatory Submissions: Serves as a characterized material for inclusion in regulatory filings (e.g., DMF, CMC sections) to support drug approval processes.

Basic Information

Product Name	8S-Cabergoline
CAS No.	856676-33-0
Molecular Formula	C26H37N5O2
Molecular Weight	451.60 g/mol
Synonyms	Cabergoline 8S-isomer; (8S)-Cabergoline; (8S)-1-[(6-Allylergolin-8β-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea; FCE-21336 (8S-isomer); Dopergine (8S-isomer)
EINECS	Contact for details

Quality Control

Our 8S-Cabergoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing results from tests including HPLC assay, chiral purity, and related substances. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (8S-isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.