Description

Samidorphan is a high-purity, selective opioid receptor antagonist with significant pharmacological research and development applications. This compound is critical for advancing studies in neuropharmacology, addiction medicine, and the development of novel combination therapies for central nervous system disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) focused on innovative therapeutic agents.

Application

• Pharmaceutical Research & Development: Key intermediate or active pharmaceutical ingredient (API) in the development of novel opioid modulation therapies.
• Neuropharmacology Studies: Used as a reference standard and tool compound in preclinical research to investigate opioid receptor function and signaling pathways.
• Combination Drug Development: Essential component in the research of fixed-dose combination products targeting opioid side-effect mitigation, such as in conjunction with antipsychotics.
• Analytical Reference Standard: Serves as a high-purity standard for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.
• Clinical Trial Material (CTM) Manufacturing: Supplied under GMP guidelines for the production of batches used in Phase I-III clinical trials.
• Mechanism of Action (MoA) Research: Employed in vitro and in vivo to elucidate the precise mechanisms and efficacy of opioid antagonist activity.

Basic Information

Product Name	Samidorphan
CAS No.	852626-89-2
Molecular Formula	C₂₄H₃₂N₂O₃
Molecular Weight	396.53 g/mol
Synonyms	Samidorphan; (3R,4R)-7-Hydroxy-3,4-dimethyl-17-(2-methylpropyl)-6-oxo-6,14-ethenomorphinan; ALKS 33; RDC-0313; 17-(Isobutyl)-6,14-ethenomorphinan-7-ol, 3,4-dimethyl-; Opioid receptor antagonist ALKS 33
EINECS	Contact for details

Quality Control

Our Samidorphan is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and rigorous impurity profiling to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.