Description

6-(4-Trifluoromethoxyphenyl)-Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct trifluoromethoxy-substituted aromatic structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors engaged in developing new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the stability imparted by the trifluoromethoxy group.
• Ligand Synthesis: Serves as a starting material for creating specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for introducing the nicotinic acid moiety with a fluorinated aromatic system.

Basic Information

Product Name	6-(4-Trifluoromethoxyphenyl)-Nicotinic Acid
CAS No.	851266-73-4
Molecular Formula	C13H8F3NO3
Molecular Weight	283.21 g/mol
Synonyms	6-[4-(Trifluoromethoxy)phenyl]pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-[4-(trifluoromethoxy)phenyl]-; 6-(4-Trifluoromethoxyphenyl)nicotinic acid; Nicotinic acid, 6-(4-trifluoromethoxyphenyl)-; 851266-73-4
EINECS	Contact for details

Quality Control

Our 6-(4-Trifluoromethoxyphenyl)-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.