Description

(S)-Gna-A(Bz)-Phosphoramidite CAS NO 851050-24-3 is a high-purity, chiral phosphoramidite building block, a critical intermediate in the automated solid-phase synthesis of oligonucleotides. Its precise stereochemistry and protective groups are essential for ensuring the fidelity and yield of complex nucleic acid sequences. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA therapeutics, and other advanced genetic medicines.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key monomer for the automated, stepwise assembly of DNA/RNA strands.
• Antisense Oligonucleotide (ASO) Development: For the production of therapeutic oligonucleotides targeting specific mRNA sequences.
• siRNA and miRNA Synthesis: A crucial component in manufacturing small interfering RNA and microRNA for gene silencing applications.
• Phosphorothioate Backbone Modification: Used in the synthesis of nuclease-resistant oligonucleotide analogs.
• Research Scale Synthesis: For exploratory synthesis of novel oligonucleotide sequences in academic and industrial R&D labs.
• GMP Manufacturing: Serves as a starting material in the Good Manufacturing Practice (GMP) production of clinical-grade oligonucleotide APIs.

Basic Information

Product Name	(S)-Gna-A(Bz)-Phosphoramidite
CAS No.	851050-24-3
Molecular Formula	C41H49N6O7P
Molecular Weight	768.85 g/mol
Synonyms	2'-Deoxy-2'-fluoro-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-Deoxy-2'-fluoro-N6-benzoyl-5'-O-DMT-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-F-A(Bz)-CE Phosphoramidite; 2'-Fluoro-2'-deoxyadenosine (N6-benzoyl) phosphoramidite; 2'-F-dA(Bz) Phosphoramidite; GNA-A(Bz) Phosphoramidite; (S)-2'-Fluoroarabinonucleic acid adenosine phosphoramidite
EINECS	Contact for details

Quality Control

Our (S)-Gna-A(Bz)-Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C under an inert atmosphere (argon or nitrogen). The product is hygroscopic (moisture-sensitive) and must be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, DCM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.