Description

3-(2-Fluoro-Phenyl)-4,5-Dihydro-Isoxazole-5-Carboxylic Acid is a high-purity fluorinated isoxazoline derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and the isoxazoline moiety into target structures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorinated isoxazoline structure can contribute to improved biological activity and environmental stability.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of libraries of novel compounds for high-throughput screening in drug discovery.
• Material Science: Potential intermediate in the synthesis of specialty polymers or functional materials that require fluorinated aromatic components for specific properties like thermal stability or hydrophobicity.

Basic Information

Product Name	3-(2-Fluoro-Phenyl)-4,5-Dihydro-Isoxazole-5-Carboxylic Acid
CAS No.	842973-70-0
Molecular Formula	C10H8FNO3
Molecular Weight	209.18 g/mol
Synonyms	5-Isoxazolecarboxylic acid, 4,5-dihydro-3-(2-fluorophenyl)-; 3-(2-Fluorophenyl)-4,5-dihydroisoxazole-5-carboxylic acid; 2-Fluoro-β,γ-dihydroisoxazole-α-carboxylic acid (phenyl derivative); 5-Carboxy-3-(2-fluorophenyl)-2-isoxazoline; Isoxazoline-5-carboxylic acid, 3-(o-fluorophenyl)-4,5-dihydro-; FLUORO-PH-Isox-CA (abbrev.); o-Fluorophenyl dihydroisoxazole carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(2-Fluoro-Phenyl)-4,5-Dihydro-Isoxazole-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing all specification results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.