Description

3-Fluoro-5-(Hydroxymethyl)Benzoic Acid is a versatile fluorinated benzoic acid derivative that serves as a key building block in advanced organic synthesis. Its bifunctional structure, featuring both a carboxylic acid and a hydroxymethyl group on a fluorinated aromatic ring, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and material science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators, where the fluorine atom can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic and photonic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to introduce fluorine and polar functional groups into specialty polymers, enhancing their chemical resistance and surface properties.
• Chemical Biology & Proteomics: Employed as a linker or tagging reagent in bioconjugation and probe development due to its reactive handles for attachment to biomolecules.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical manufacturers for use in multi-step custom synthesis projects for clients across various high-tech industries.

Basic Information

Product Name	3-Fluoro-5-(Hydroxymethyl)Benzoic Acid
CAS No.	816449-67-9
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	5-(Hydroxymethyl)-3-fluorobenzoic Acid; 3-Fluoro-5-(hydroxymethyl)benzoic acid; Benzoic acid, 3-fluoro-5-(hydroxymethyl)-; 3-Fluoro-5-hydroxymethylbenzoic Acid; 3-F-5-HMBA; 816449-67-9; 3-Fluoro-5-(hydroxymethyl)benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-(Hydroxymethyl)Benzoic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes compliance with relevant ICH guidelines for impurities. A detailed Certificate of Analysis (COA) providing batch-specific results for purity, related substances, and residual solvents is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.